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Papers of the Week

Papers: 31 Oct 2020 - 6 Nov 2020

Animal Studies, Human Studies, Pharmacology/Drug Development


Clin Transl Immunology



Blockade of IL-33 signalling attenuates osteoarthritis.


He Z, Song Y, Yi Y, Qiu F, Wang J, Li J, Jin Q, Sacitharan P K
Clin Transl Immunology. 2020; 9(10):e1185.
PMID: 33133598.


Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available. The critical unmet need is to find therapeutic targets to reduce both disease progression and pain. The cytokine IL-33 and its receptor ST2 have been shown to play a role in immune and inflammatory diseases, but their role in osteoarthritis is unknown.