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Papers of the Week


2020


Drug Des Devel Ther


14

Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats.

Authors

Wang Q-S, Xu B-X, Fan K-J, Li Y-W, Wu J, Wang T-Y
Drug Des Devel Ther. 2020; 14:4101-4113.
PMID: 33116399.

Abstract

To overcome negative adverse effects and improve therapeutic index of dexamethasone (Dex) in rheumatoid arthritis (RA), we developed a novel sustained release formulation-intra-articular injectable dexamethasone-loaded thermosensitive hydrogel (DLTH) with chitosan-glycerin-borax as carrier for the remission of inflammation and pain. The focus of this article is to explore both anti-inflammatory and pain-relieving effects of DLTH joint injection in bovine type-II collagen-induced arthritis (CIA) rats.