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Papers of the Week

Papers: 24 Oct 2020 - 30 Oct 2020

2020 Oct 28

Pain Manag

Noninvasive vagal nerve stimulation for gastroenterology pain disorders.


Gottfried-Blackmore A, Habtezion A, Nguyen L
Pain Manag. 2020 Oct 28.
PMID: 33111642.


Abdominal pain continues to be a major challenge and unmet need in clinical practice. Normalization of bidirectional gut-brain signaling has generated much interest as a therapeutic approach to treat chronic abdominal pain. Vagal nerve stimulation (VNS) is emerging as a potential non-pharmacologic strategy for the treatment of abdominal pain. In this review paper, we will summarize the etiologies of chronic pain in gastrointestinal disorders and discuss the rational for VNS as a therapeutic approach to chronic abdominal pain, with particular emphasis in the gammaCore stimulator which allows for noninvasive VNS.