I am a
Home I AM A Search Login

Papers of the Week

2020 Oct 23

Eur J Neurol

Serum neurofilament increases after ascent to 4559m but is not related to acute mountain sickness.


Sareban M, Berger M M, Pinter D, Buchmann A, Macholz F, Schmidt P, Schiefer L, Schimke M, Niebauer J, Steinacker J M, Treff G, Khalil M
Eur J Neurol. 2020 Oct 23.
PMID: 33095952.


At high altitude the brain is exposed to hypoxic stress, which may result in neurological conditions with acute mountain sickness (AMS) being the most common one. We hypothesized that rapid ascent to high altitude alters neuro-axonal integrity that can be detected by increased concentration of serum neurofilament light (sNfL) in the blood and may be even exaggerated in subjects with AMS.