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Papers of the Week

Papers: 10 Oct 2020 - 16 Oct 2020


Human Studies

2020 Oct 10

J Clin Rheumatol

Correlation Between Corneal Nerve Density and Symptoms of Small Fiber Neuropathy in Patients With Fibromyalgia: The Confounding Role of Severe Anxiety or Depression.


Ramírez M, Guerra-Juárez A, Miyake D-Y, Sebastian-Arellano C, Estrada-Mata A-G, González-Moyotl N-J, Rodríguez-Aguayo A-M, Martínez-Lavin M, Martínez-Martínez L-A
J Clin Rheumatol. 2020 Oct 10.
PMID: 33044388.


A consistent line of investigation proposes fibromyalgia as a dysautonomia-associated neuropathic pain syndrome. Comorbid anxiety or depression amplifies fibromyalgia symptoms. The recent recognition of small fiber neuropathy in fibromyalgia patients supports the neuropathic nature of the illness. Corneal confocal microscopy accurately identifies small nerve fiber pathology. The newly developed Small-Fiber Symptom Survey captures the spectrum of small fiber neuropathy symptoms. We aimed to correlate corneal nerve density with different fibromyalgia disease severity questionnaires including the Small-Fiber Symptom Survey. We defined the possible confounding role of comorbid anxiety or depression severity in the clinical-pathological association.