I am a
Home I AM A Search Login

Papers of the Week

Papers: 3 Oct 2020 - 9 Oct 2020

Animal Studies

2020 Oct 06


Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS.


Perna E, Aguilera-Lizarraga J, Florens MV, Jain P, Theofanous SA, Hanning N, De Man JG, Berg M, De Winter B, Alpizar YA, Talavera K, Vanden Berghe P, Wouters M, Boeckxstaens G
Gut. 2020 Oct 06.
PMID: 33023902.


Resolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation. To what extent these molecules could also have a beneficial effect on TRPV1 sensitisation and visceral hypersensitivity (VHS), mechanisms involved in IBS, remains unknown.