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Papers of the Week

Papers: 3 Oct 2020 - 9 Oct 2020

Animal Studies


2020 Oct 05

Ann Neurol

Optogenetic spreading depression elicits trigeminal pain and anxiety behavior.


Harriott AM, Chung DY, Uner A, Bozdayi RO, Morais A, Takizawa T, Qin T, Ayata C
Ann Neurol. 2020 Oct 05.
PMID: 33016466.


Cortical spreading depression (SD) is an intense depolarization underlying migraine aura. Despite the weight of evidence linking SD to the pain phase of migraine, controversy remains over a causal role of SD in cephalgia because of the invasive nature of previous SD induction methods. To overcome this problem, we employed a novel minimally invasive optogenetic SD induction method and examined the effect SD on behavior.