I am a
Home I AM A Search Login

Papers of the Week

Papers: 26 Sep 2020 - 2 Oct 2020

Animal Studies, Pharmacology/Drug Development

2020 Sep 28

Pharm Res



Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System.


Chiang M, Back H-M, Lee J B, Oh S, Guo T, Girgis S, Park C, Haroutounian S, Kagan L
Pharm Res. 2020 Sep 28; 37(10):205.
PMID: 32989520.


Modulation of 5-HT3 receptor in the central nervous system (CNS) is a promising approach for treatment of neuropathic pain. The goal was to evaluate the role of P-glycoprotein (Pgp) in limiting exposure of different parts of the CNS to ondansetron (5-HT3 receptor antagonist) using wild-type and genetic knockout rat model.