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Papers: 26 Sep 2020 - 2 Oct 2020
Animal Studies, Pharmacology/Drug Development
2020 Sep 28
Pharm Res
37
10
Modulation of 5-HT3 receptor in the central nervous system (CNS) is a promising approach for treatment of neuropathic pain. The goal was to evaluate the role of P-glycoprotein (Pgp) in limiting exposure of different parts of the CNS to ondansetron (5-HT3 receptor antagonist) using wild-type and genetic knockout rat model.