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Papers of the Week
Blockade of Bradykinin Receptors or Angiotensin II Type 2 Receptor Prevents Paclitaxel-Associated Acute Pain Syndrome in Mice.
Abstract
Paclitaxel (PCX) is the first-line choice for the treatment of several types of cancer, including breast, ovarian and lung cancers. However, patients who receive even a single dose with PCX commonly develop mechanical and cold allodynia, a symptom known as PCX-associated acute pain syndrome (P-APS). Here we assessed possible involvement of kinin-kallikrein and renin-angiotensin systems in P-APS in mice.