I am a
Home I AM A Search Login

Papers of the Week

Papers: 19 Sep 2020 - 25 Sep 2020

Animal Studies, Pharmacology/Drug Development

2020 Sep 23

Eur J Pain

Blockade of Bradykinin Receptors or Angiotensin II Type 2 Receptor Prevents Paclitaxel-Associated Acute Pain Syndrome in Mice.


Zanata GC, Pinto LG, da Silva NR, Lopes AHP, de Oliveira FFB, Schivo IRS, Cunha FQ, McNaughton P, Cunha TM, Silva RL
Eur J Pain. 2020 Sep 23.
PMID: 32965065.


Paclitaxel (PCX) is the first-line choice for the treatment of several types of cancer, including breast, ovarian and lung cancers. However, patients who receive even a single dose with PCX commonly develop mechanical and cold allodynia, a symptom known as PCX-associated acute pain syndrome (P-APS). Here we assessed possible involvement of kinin-kallikrein and renin-angiotensin systems in P-APS in mice.