I am a
Home I AM A Search Login

Papers of the Week

Papers: 19 Sep 2020 - 25 Sep 2020

Animal Studies, Human Studies

2020 Sep 20

Ann Neurol

Editor's Pick

Keratinocytes communicate with sensory neurons via synaptic-like contacts.


Talagas M, Lebonvallet N, Leschiera R, Sinquin G, Elies P, Haftek M, Pennec J-P, Ressnikoff D, La Padula V, Le Garrec R, L'Herondelle K, Mignen O, Le Pottier L, Kerfant N, Reux A, Marcorelles P, Misery L
Ann Neurol. 2020 Sep 20.
PMID: 32951274.


Pain, temperature and itch are conventionally thought to be exclusively transduced by the intraepidermal nerve endings. While recent studies have shown that epidermal keratinocytes also participate in sensory transduction, the mechanism underlying keratinocyte communication with intraepidermal nerve endings remains poorly understood. We sought to demonstrate the synaptic character of the contacts between keratinocytes and sensory neurons and their involvement in sensory communication between keratinocytes and sensory neurons.