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Papers: 19 Sep 2020 - 25 Sep 2020


2020 Sep 17

Syst Rev



Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis.


Bussières A, Hartvigsen J, Ferreira ML, Ferreira PH, Hancock MJ, Stone LS, Wideman TH, Boruff J, Elklit A
Syst Rev. 2020 Sep 17; 9(1):215.
PMID: 32943108.


A growing body of research highlights the pervasive harms of adverse childhood experiences (ACEs) on health throughout the life-course. However, findings from prior reviews and recent longitudinal studies investigating the association between types of ACEs and persistent pain have yielded inconsistent findings in the strength and direction of associations. The purpose of this review is to appraise and summarize evidence on the relationship between ACEs and persistent pain and disability outcomes in adulthood. The specific aims are (1) to determine whether there is a relationship between exposure to ACE and persistent pain and disability in adults and (2) to determine whether unique and cumulative ACEs exposures (number and type) increase the risk of developing persistent pain and disability in adulthood.