I am a
Home I AM A Search Login

Papers of the Week

2020 Sep 14


Opioid-free recovery after herniorrhaphy with HTX-011 as the foundation of a multimodal analgesic regimen.


Singla N, Winkle P, Bertoch T, Hu J, Beaton A, Redan J
Surgery. 2020 Sep 14.
PMID: 32943200.


Most severe pain occurs within the first 72 hours after an operation, and current local anesthetics have a limited duration of action. HTX-011 is a dual-acting, local anesthetic containing bupivacaine, and low-dose meloxicam in an extended-release polymer. In a prior phase 3 inguinal herniorrhaphy study, HTX-011 alone provided superior pain relief for 72 hours and significantly decreased opioid use compared with saline placebo and bupivacaine hydrochloride. This open-label study assessed the safety, efficacy, and opioid-sparing properties of HTX-011 as the foundation of a scheduled, nonopioid, multimodal analgesia regimen in patients undergoing open inguinal herniorrhaphy.