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Drug Des Devel Ther


Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study.


Li X, Lv X, Jiang Z, Nie X, Wang X, Li T, Zhang L, Liu S
Drug Des Devel Ther. 2020; 14:3509-3518.
PMID: 32943843.


Propofol for procedural sedation and analgesia (PSA) for colonoscopy can result in a high prevalence of severe respiratory depression. Studies have shown that intravenous (IV) infusion of lidocaine can reduce propofol requirements significantly and increase the ventilatory response to carbon dioxide in humans. We tested the hypothesis that IV lidocaine could improve propofol-induced respiratory depression in obese patients during colonoscopy.