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Papers of the Week

2020 Aug

Turk J Pharm Sci



Investigation of the Peripheral Analgesic Activity of Oxicams and Their Combinations with Caffeine.


Syrova A, Lukyanova L, Kozub S, Zavada O, Levashova O, Shaposhnik V
Turk J Pharm Sci. 2020 Aug; 17(4):408-411.
PMID: 32939136.


Therapy of pain syndromes involves exposure to its source, receptors, and peripheral fibers. Treatment of acute pain and inflammation involves the use of nonsteroidal anti-inflammatory drugs and nonnarcotic analgesics. An alternative to obsolete analgesics is combined compositions. Experimental results clearly indicates that caffeine effectively enhances the peripheral analgesic activity when combined in an analgesic. The aim of the present study was to evaluate the peripheral analgesic activity of meloxicam, piroxicam, and their pharmacological combinations with caffeine.