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Papers of the Week

Papers: 12 Sep 2020 - 18 Sep 2020

Animal Studies, Pharmacology/Drug Development

2020 Sep 14

Biomed Pharmacother


The analgesic effects of pioglitazone in the bone cancer pain rats via regulating the PPARγ/PTEN/mTOR signaling pathway in the spinal dorsal horn.


Gu W, Sun Y'e, Gu W, Huang Y, Bo J, Zhou L, Ma Z, Gu X, Zhang W
Biomed Pharmacother. 2020 Sep 14; 131:110692.
PMID: 32942156.


Bone cancer pain (BCP) remains a difficult clinical problem. This study examined whether pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, is effective for attenuating BCP, and investigated the interaction between activation of PPARγ and phosphatase and tensin homolog deleted from chromosome 10 (PTEN) / mammalian target of rapamycin (mTOR) signal in the spinal dorsal horn (SDH) of BCP rats.