I am a
Home I AM A Search Login

Papers of the Week


Papers: 12 Sep 2020 - 18 Sep 2020

RESEARCH TYPE:
Psychology


Human Studies


2020 Sep 01


JAMA Netw Open


3


9

Assessment of Placebo Response in Objective and Subjective Outcome Measures in Rheumatoid Arthritis Clinical Trials.

Authors

Vollert J, Cook NR, Kaptchuk TJ, Sehra ST, Tobias DK, Hall KT
JAMA Netw Open. 2020 Sep 01; 3(9):e2013196.
PMID: 32936297.

Abstract

Large placebo responses in randomized clinical trials may keep effective medication from reaching the market. Primary outcome measures of clinical trials have shifted from patient-reported to objective outcomes, partly because response to randomized placebo treatment is thought to be greater in subjective compared with objective outcomes. However, a direct comparison of placebo response in subjective and objective outcomes in the same patient population is missing.