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Papers of the Week

Papers: 12 Sep 2020 - 18 Sep 2020

Animal Studies, Pharmacology/Drug Development

2020 Sep 14

Reg Anesth Pain Med

Role of peripheral sensory neuron mu-opioid receptors in nociceptive, inflammatory, and neuropathic pain.


Barpujari A, Ford N, He S-Q, Huang Q, Gaveriaux-Ruff C, Dong X, Guan Y, Raja S
Reg Anesth Pain Med. 2020 Sep 14.
PMID: 32928995.


The role of peripheral mu-opioid receptors (MOPs) in chronic pain conditions is not well understood. Here, we used a combination of mouse genetics, behavioral assays, and pharmacologic interventions to investigate the contribution of primary afferent MOPs to nociceptive, inflammatory, and neuropathic pain, as well as to opioid analgesia.