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Papers of the Week

2020 Sep 11

Pain Med

Pain May Promote Tumor Progression via Substance P-Dependent Modulation of Toll-like Receptor-4.


Yang C, Sun Y, Ouyang X, Li J, Zhu Z, Yu R, Wang L, Jia L, Ding G, Wang Y, Jiang F
Pain Med. 2020 Sep 11.
PMID: 32914185.


In a previous study, persistent pain was suggested to be a risk factor for tumor patients. However, the mechanism underlying this phenomenon is still unclear. Substance P (SP), a pain-related neuropeptide secreted by the neural system and the immune system, plays an important role in the induction and maintenance of persistent pain.