A large number of productive age populations in Indonesia are tagged reliable human resources, assuming they have a good quality of life (QoL). This study aims to examine the determinant factors related to QoL based on the 2014 Indonesia Family Life Survey. This is a population-based cross-sectional study comprising 13 368 participants aged 15 to 64 years from 23 provinces. The analysis was carried out to construct a composite indicator of QoL. The result showed that the low prevalence of 54% among the general population needs to be ameliorated. Demographic factors (eg, age, marital status, and education), primary activities, pain, and chronic illnesses were significantly related to QoL and used to provide supporting information.