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Papers of the Week

Papers: 12 Sep 2020 - 18 Sep 2020

Animal Studies

2020 Sep 10

Rheumatology (Oxford)

Dorsal horn disinhibition and movement-induced behaviour in a rat model of inflammatory arthritis.


Locke S, Yousefpour N, Ribeiro-da-Silva A
Rheumatology (Oxford). 2020 Sep 10.
PMID: 32910183.


Alterations beyond joint inflammation such as changes in dorsal horn (DH) excitability contribute to pain in inflammatory arthritis (IA). More complete understanding of specific underlying mechanisms will be important to define novel targets for the treatment of IA pain. Pre-clinical models are useful, but relevant pain assays are vital for successful clinical translation. For this purpose, a method is presented to assess movement-induced pain-related behaviour changes that was subsequently used to investigate DH disinhibition in IA.