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Int J Chron Obstruct Pulmon Dis


Allopurinol in Patients with Pulmonary Hypertension Associated with Chronic Lung Disease.


Liu-Shiu-Cheong PSK, Lipworth BJ, Weir-McCall JR, Houston GJ, Struthers AD
Int J Chron Obstruct Pulmon Dis. 2020; 15:2015-2024.
PMID: 32904701.


Oxidative stress (OS) has been implicated in the development of pulmonary hypertension (PH) and ventricular hypertrophy. Xanthine oxidase is a well-recognised source of reactive oxygen species, which lead to OS. The aim of this proof of concept study was to assess whether allopurinol (xanthine oxidase inhibitor) would reduce right ventricular mass (RVM) in patients with PH-associated chronic lung disease (PH-CLD).