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Papers of the Week

Papers: 5 Sep 2020 - 11 Sep 2020

Animal Studies, Pharmacology/Drug Development

2020 Sep 07

Neuropsychopharmacol Rep

Lack of rewarding effects of a soluble epoxide hydrolase inhibitor TPPU in mice: Comparison with morphine.


Wan X, Fujita Y, Chang L, Wei Y, Ma L, Wuyun G, Pu Y, Hammock BD, Hashimoto K
Neuropsychopharmacol Rep. 2020 Sep 07.
PMID: 32896112.


Although opioids have been used as treatment of neuropathic pain, opioids have abuse potential in humans. Since soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids plays a key role in the pain, sEH inhibitors would be promising new therapeutic drugs for neuropathic pain. In this study, we examined the effect of the sEH inhibitor TPPU on rewarding effects in mice using the conditioned place preference (CPP) paradigm.