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Papers of the Week

Papers: 29 Aug 2020 - 4 Sep 2020

Animal Studies

2020 Aug 27


HDAC3 in hippocampus contributes to memory impairment following chronic constriction injury of sciatic nerve in mice.


Zhang G-F, Zhou Z-Q, Guo J, Gu H-W, Su M-Z, Yu B-C, Zhou F, Han B-Y, Jia M, Ji M-H, Tao Y-X, Zhao C-J, Yang J-J
Pain. 2020 Aug 27.
PMID: 32868749.


Chronic neuropathic pain is frequently accompanied by memory impairment, yet the underlying mechanisms remain unclear. Here we showed that mice displayed memory impairment starting at 14 days and lasting for at least 21 days after chronic constriction injury (CCI) of unilateral sciatic nerve in mice. Systemic administration of the pan histone deacetylase (HDAC) inhibitor sodium butyrate attenuated this memory impairment. More specifically, we found that hippocampus HDAC3 was involved in this process because the levels of its mRNA and protein increased significantly in the hippocampus at 14 and 21 days after CCI, but not sham surgery. Systemic administration of the selective HDAC3 antagonist RGPF966 attenuated CCI-induced memory impairment, improved hippocampal long-term potentiation impairment and rescued reductions of dendritic spine density and synaptic plasticity-associated protein in the hippocampus. Additionally, HDAC3 overexpression in the hippocampus led to memory impairment without affecting basal nociceptive responses in naive mice. Our findings suggest that HDAC3 contributes to memory impairment after CCI by impairing synaptic plasticity in hippocampus. HDAC3 might serve as a potential molecular target for therapeutic treatment of memory impairment under neuropathic pain conditions.