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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Evaluation of Long-Time Decoction-Detoxicated (Processed Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis.

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2020


Front Pharmacol


http://www.ncbi.nlm.nih.gov/pubmed/32848727?dopt=Abstract


11

Evaluation of Long-Time Decoction-Detoxicated (Processed Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis.

Authors

Evaluation of Long-Time Decoction-Detoxicated (Processed Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis.
Zhang L, Li T, Wang R, Xu J, Zhou L, Yan L, Hu Z, Li H, Liu F, Du W, Tong P, Wu H, Zhang S, Shan L, Efferth T
Front Pharmacol. 2020; 11:1053.
PMID: 32848727.

Abstract

As a degenerative joint disease with severe cartilage destruction and pain, osteoarthritis (OA) has no satisfactory therapy to date. In traditional Chinese medicine (TCM), Debeaux derived () has been developed for joint pain treatment. However, it causes adverse events in OA patients. Long-time decoction has been traditionally applied to reduce the aconite toxicity of and other aconite herbs, but its detoxifying effect is uncertain.
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