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Papers of the Week

2020 Aug 26

Curr Pharm Des

Flavonoids as potential therapeutic agents for the management of diabetic neuropathy.


Sood A, Kumar B, Singh S K, Prashar P, Gautam A, Gulati M, Pandey N K, Melkani I, Awasthi A, Saraf SA, Vidari G, Ozdemir M, Hussain F H S, Anwar E T, Ameen M S M, Gupta S, Porwal O
Curr Pharm Des. 2020 Aug 26.
PMID: 32851955.


Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathway and leads to secondary complications such as neuropathy, retinopathy, nephropathy and cardiomyopathy. Among them, management of diabetic neuropathy is one of the major challenges for physicians as the well pharmaceutical industries. Naturally occurring flavonoids are extensively used for the treatment of diabetes and its complications due to their antioxidant properties. Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products and inhibition of the the α-glucosidase enzyme. This review entails current updates on therapeutic perspectives of flavonoids in the treatment of neuropathic pain. This manuscript explains pathological aspects of neuropathic pain, the chemistry of flavonoids, and their application in amelioration of neuropathic pain through preclinical studies either alone or in combination with other therapeutic agents. Keywords: Flavonoids, diabetic neuropathy, oxidative stress, glycogenolysis, α-glucosidase .