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Papers of the Week

2020 Aug 19

Drug Alcohol Depend


Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving.


Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li C-SR
Drug Alcohol Depend. 2020 Aug 19; 216:108240.
PMID: 32853997.


Withdrawal from chronic cocaine use leads to anxiety and dysphoria that may perpetuate habitual drug use. The pain circuit is widely implicated in the processing and manifestations of negative emotions. Numerous studies have focused on characterizing reward circuit dysfunction but relatively little is known about the pain circuit response during cocaine withdrawal.