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Papers of the Week

Papers: 29 Aug 2020 - 4 Sep 2020

Animal Studies

2020 Aug 27

Arthritis Res Ther



The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis.


Blom AB, van den Bosch MH, Blaney Davidson EN, Roth J, Vogl T, van de Loo FA, Koenders M, Van der Kraan PM, Geven EJ, van Lent PL
Arthritis Res Ther. 2020 Aug 27; 22(1):199.
PMID: 32854769.


Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role of S100A9 in pain response during acute synovitis.