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Papers of the Week


Papers: 22 Aug 2020 - 28 Aug 2020


Human Studies


2020 Aug 26


Cephalalgia

Opening of BK channels alters cerebral hemodynamic and causes headache in healthy volunteers.

Authors

Al-Karagholi M A-M, Ghanizada H, Nielsen C A W, Skandarioon C, Snellman J, Lopez-Lopez C, Hansen J M, Ashina M
Cephalalgia. 2020 Aug 26:333102420940681.
PMID: 32847403.

Abstract

Preclinical data implicate large conductance calcium-activated potassium (BK) channels in the pathogenesis of headache and migraine, but the exact role of these channels is still unknown. Here, we investigated whether opening of BK channels would cause headache and vascular effects in healthy volunteers.