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Papers of the Week

Papers: 22 Aug 2020 - 28 Aug 2020

Human Studies

2020 Aug 26


Opening of BK channels alters cerebral hemodynamic and causes headache in healthy volunteers.


Al-Karagholi M A-M, Ghanizada H, Nielsen C A W, Skandarioon C, Snellman J, Lopez-Lopez C, Hansen J M, Ashina M
Cephalalgia. 2020 Aug 26:333102420940681.
PMID: 32847403.


Preclinical data implicate large conductance calcium-activated potassium (BK) channels in the pathogenesis of headache and migraine, but the exact role of these channels is still unknown. Here, we investigated whether opening of BK channels would cause headache and vascular effects in healthy volunteers.