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Papers of the Week

Papers: 22 Aug 2020 - 28 Aug 2020

Animal Studies, Pharmacology/Drug Development

2020 Aug 27

Br J Pharmacol

TREK-1 channel activation as a new analgesic strategy devoid of opioid adverse effects.


Busserolles J, Ben Soussia I, Pouchol L, Marie N, Meleine M, Devilliers M, Judon C, Schopp J, Clémenceau L, Poupon L, Chapuy E, Richard S, Noble F, Lesage F, Ducki S, Eschalier A, Lolignier S
Br J Pharmacol. 2020 Aug 27.
PMID: 32851651.


Opioids are effective painkillers. However, their risk-benefit ratio is dampened by numerous adverse effects and opioid misuse has led to a public health crisis. Safer alternatives are required but isolating the antinociceptive effect of opioids from their adverse effects is a pharmacological challenge because activation of the mu opioid receptor triggers both the antinociceptive and adverse effects of opioids.