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Papers of the Week

2020 Aug 18

Anticancer Agents Med Chem

Benzimidazole Derivative Ameliorates Opioid-mediated Tolerance during Anticancer-Induced Neuropathic Pain in mice.


Akhtar S, Abbas M, Naeem K, Faheem M, Nadeem H, Mehmood A
Anticancer Agents Med Chem. 2020 Aug 18.
PMID: 32819235.


Cancer is known to be the second significant cause of death worldwide. Chemotherapeutic agents such as platinum-based compounds are frequently used single-handedly or accompanied with additional chemotherapies to treat cancer patients. Chemotherapy-inducedperipheral painful neuropathy is seen in around 40% of patient who are treated with platinum-based compounds including cisplatin. This not only decreases quality of life of patients but also patients' compliance to cisplatin.