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Papers of the Week

Papers: 22 Aug 2020 - 28 Aug 2020

Animal Studies, Pharmacology/Drug Development


2020 Aug 17

Br J Anaesth

Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.


Ding H, Kiguchi N, Perrey DA, Nguyen T, Czoty PW, Hsu F-C, Zhang Y, Ko M-C
Br J Anaesth. 2020 Aug 17.
PMID: 32819621.


A novel G-protein signalling-biased mu opioid peptide (MOP) receptor agonist, PZM21, was recently developed with a distinct chemical structure. It is a potent G activator with minimal β-arrestin-2 recruitment. Despite intriguing activity in rodent models, PZM21 function in non-human primates is unknown. The aim of this study was to investigate PZM21 actions after systemic or intrathecal administration in primates.