I am a
Home I AM A Search Login

Papers of the Week

Papers: 15 Aug 2020 - 21 Aug 2020


2020 Aug 18

Br J Dermatol

Prevalence, pathophysiology and management of itch in epidermolysis bullosa.


Papanikolaou M, Onoufriadis A, Mellerio JE, Nattkemper L, Yosipovitch G, Steinhoff M, McGrath JA
Br J Dermatol. 2020 Aug 18.
PMID: 32810291.


Epidermolysis bullosa (EB) is a highly diverse group of inherited skin disorders, resulting from mutations in genes encoding proteins of the dermal-epidermal junction (DEJ). Itch (pruritus) is one of the commonest symptoms across all EB subtypes. It occurs in blistered or wounded sites, or manifests as a generalized phenomenon, thereby affecting both intact skin and healing wounds. The mechanism of pruritus in EB is unclear. It is likely that skin inflammation secondary to barrier disruption, wound healing cascades and dysregulated activation of epidermal sensory nerve endings are all involved in its pathophysiology on the molecular and cellular level. Understanding these mechanisms in depth is crucial in developing optimised treatments for people with EB and improving quality of life. This review summarises current evidence on the prevalence, mechanisms and management of itch in EB.