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Papers of the Week

Papers: 15 Aug 2020 - 21 Aug 2020

Animal Studies, Pharmacology/Drug Development


J Exp Pharmacol


Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics.


N Mohammadi E, Louwies T, Pietra C, Northrup RS, Meerveld B G-V
J Exp Pharmacol. 2020; 12:267-274.
PMID: 32801950.


The anti-nociceptive properties of ghrelin have been demonstrated in alleviating inflammatory and neuropathic pain. Whether a ghrelin receptor-mediated mechanism attenuates visceral and somatic pain in the absence of active inflammation remains to be explored. Here, we investigate the efficacy of peripherally restricted (ipamorelin) and a globally active (HM01) selective ghrelin receptor agonist in an experimental model of non-inflammatory visceral hypersensitivity and somatic mechanical allodynia.