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Papers of the Week

Papers: 15 Aug 2020 - 21 Aug 2020

Human Studies

2020 Aug 13

Eur J Pain

Pain-autonomic interaction: a surrogate marker of central sensitization.


Scheuren PS, Rosner J, Curt A, Hubli M
Eur J Pain. 2020 Aug 13.
PMID: 32794307.


Central sensitization represents a key pathophysiological mechanism underlying the development of neuropathic pain, often manifested clinically as mechanical allodynia and hyperalgesia. Adopting a mechanism-based treatment approach relies highly on the ability to assess the presence of central sensitization. The aim of the study was to investigate potential pain-autonomic readouts to operationalize experimentally induced central sensitization in the area of secondary hyperalgesia.