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Papers of the Week

Papers: 8 Aug 2020 - 14 Aug 2020

Human Studies, Pharmacology/Drug Development

2020 Sep




Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine.


Dahan A, van Dam JC, Niesters M, van Velzen M, Fossler MJ, Demitrack MA, Olofsen E
Anesthesiology. 2020 Sep; 133(3):559-568.
PMID: 32788558.


To improve understanding of the respiratory behavior of oliceridine, a μ-opioid receptor agonist that selectively engages the G-protein-coupled signaling pathway with reduced activation of the β-arrestin pathway, the authors compared its utility function with that of morphine. It was hypothesized that at equianalgesia, oliceridine will produce less respiratory depression than morphine and that this is reflected in a superior utility.