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Papers of the Week

Papers: 8 Aug 2020 - 14 Aug 2020


Human Studies

2020 Jul-Aug

Pain Rep



Conditioning open-label placebo: a pilot pharmacobehavioral approach for opioid dose reduction and pain control.


Morales-Quezada L, Mesia-Toledo I, Estudillo-Guerra A, O'Connor KC, Schneider JC, Sohn DJ, Crandell DM, Kaptchuk T, Zafonte R
Pain Rep. 2020 Jul-Aug; 5(4):e828.
PMID: 32766465.


Opioid consumption for those in comprehensive inpatient rehabilitation units is high because of the complexity of their injuries. Notably, pain in rehabilitation leads to worsened clinical outcomes because of maladaptive behaviors and poor engagement during therapies. It is critical to developing evidence-based pharmacobehavioral interventions. Based on principles of classical conditioning, conditioning open-label placebo (COLP) is a promising approach for reducing opioid use in comprehensive inpatient rehabilitation, and this technique takes advantage of the possibility of association learning and opioid pharmacology to promote evoked placebo-driven analgesia.