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Papers of the Week

2020 Jul 31

Medicine (Baltimore)



Cortical thickness in chronic pain: A protocol for systematic review and meta-analysis.


Ma HR, Sheng LQ, Chen F, Yuan CH, Dai ZY, Pan PL
Medicine (Baltimore). 2020 Jul 31; 99(31):e21499.
PMID: 32756184.


Numerous studies using a variety of non-invasive neuroimaging techniques in vivo have demonstrated that chronic pain (CP) is associated with brain alterations. Cortical thickness (CTh) via surface-based morphometry (SBM) analysis of magnetic resonance imaging data is a valid and sensitive method to investigate the structure of brain gray matter. Many studies have employed SBM to measure CTh difference between patients with CP and pain-free controls and provided important insights into the brain basis of CP. However, the findings from these studies were inconsistent and have not been quantitatively reviewed.