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2020 Aug 05

Br J Dermatol

Diagnosis of Mycoplasma aetiology in Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.


Russell E, Walker S, McPherson T
Br J Dermatol. 2020 Aug 05.
PMID: 32757268.


We were pleased that the first national guidelines for paediatric Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN) were published in your journal last year . They highlighted the higher rate of infectious triggers in children compared to adults. This message is especially important for us, as author SW's son had SJS/TEN triggered by Mycoplasma pneumoniae, which accounts for up to 50% of infectious causes. SW experienced first-hand the frustration of aetiological uncertainty in this disease. Accurate diagnosis of Mycoplasma-induced SJS/TEN is important as it allows for continuation of simple analgesia (otherwise implicated as a possible trigger), possible avoidance of further drug allergy testing (which can be inconclusive), focused treatment of Mycoplasma with antibiotics, and management of recurrence risk.