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Papers of the Week

2020 Aug 06

Int J Clin Oncol

FLOX (5-fluorouracil + leucovorin + oxaliplatin) chemotherapy for colorectal cancer leads to long-term orofacial neurotoxicity: a STROBE-guided longitudinal prospective study.


de Albuquerque Ribeiro Gondinho P, de Barros Silva P G, Lisboa M R P, Costa B A, da Rocha Filho D R, Gifoni M A C, Lima M V A, Junior R C P L, Vale M L
Int J Clin Oncol. 2020 Aug 06.
PMID: 32761281.


Colorectal carcinoma (CRC) is widely treated by chemotherapy based on an intensely neurotoxic drug: oxaliplatin (OXL). We objective to evaluate prospectively the orofacial neurotoxicity during FLOX (fluorouracil + leucovorin + OXL) chemotherapy.