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Papers of the Week

Papers: 1 Aug 2020 - 7 Aug 2020

Human Studies


J Pain Res


Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells.


Liu J, Que K, Liu Y, Zang C, Wen J
J Pain Res. 2020; 13:1655-1664.
PMID: 32753941.


Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is a promiscuous chemical nociceptor involved in the perception of cold hypersensitivity, mechanical hyperalgesia and inflammatory pain in human odontoblasts (HODs). Here, we aimed to study the underlying mechanism in which inflammatory cytokine tumor necrosis factor (TNF)-α regulated the expression of TRPA1 channel at both cellular and subcellular levels.