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Papers of the Week

Papers: 1 Aug 2020 - 7 Aug 2020


Animal Studies

2020 Aug 02

Neurogastroenterol Motil

Histone H3K9 methylation regulates chronic stress and IL-6-induced colon epithelial permeability and visceral pain.


Wiley JW, Zong Y, Zheng G, Zhu S, Hong S
Neurogastroenterol Motil. 2020 Aug 02:e13941.
PMID: 32743845.


Chronic stress is associated with activation of the HPA axis, elevation in pro-inflammatory cytokines, decrease in intestinal epithelial cell tight junction (TJ) proteins, and enhanced visceral pain. It is unknown whether epigenetic regulatory pathways play a role in chronic stress-induced intestinal barrier dysfunction and visceral hyperalgesia.