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Papers of the Week

2020 Jul 23

Psychopharmacol Bull



Naldemedine for the Use of Management of Opioid Induced Constipation.


Urits I, Patel A, Kiernan H C, Clay C J, Monteferrante N, Jung J W, Berger AA, Kassem H, Hasoon J, Kaye AD, Kaye AM, Viswanath O
Psychopharmacol Bull. 2020 Jul 23; 50(3):97-118.
PMID: 32733114.


Opioid medications are a pillar of acute and chronic analgesia, though their use is often accompanied by side-effects, such as opioid-induced constipation. Unfortunately, tolerance rarely develops to this untoward side effect. This review presents the background, evidence, and indications for the use of Naldemedine (Brand name Symproic 0.2 mg tablets) to treat opioid-induced constipation.