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Papers: 25 Jul 2020 - 31 Jul 2020

2020 Jul 28

Reg Anesth Pain Med

Differences in patient characteristics and external validity of randomized clinical trials on pain management following total hip and knee arthroplasty: a systematic review.


Pedersen C, Troensegaard H, Laigaard J, Koyuncu S, Schrøder H M, Overgaard S, Mathiesen O, Højer Karlsen A P
Reg Anesth Pain Med. 2020 Jul 28.
PMID: 32723841.


The external validity of randomized controlled trials (RCTs) is critical for the relevance of trial results in a clinical setting. We aimed to assess the external validity of RCTs investigating postoperative pain treatment after total hip and knee arthroplasty (THA and TKA) by comparing patient characteristics in these trials with a clinical cohort. Further, we assessed the use of exclusion criteria of the included RCTs.