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Papers of the Week

Papers: 18 Jul 2020 - 24 Jul 2020

Human Studies

2020 Jul 21

Cell Rep



Editor's Pick

Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K6.4 Subunit.


Lee MC, Nahorski MS, Hockley JRF, Lu VB, Ison G, Pattison LA, Callejo G, Stouffer K, Fletcher E, Brown C, Drissi I, Wheeler D, Ernfors P, Menon D, Reimann F, Smith E S J, Woods GC
Cell Rep. 2020 Jul 21; 32(3):107941.
PMID: 32697988.


By studying healthy women who do not request analgesia during their first delivery, we investigate genetic effects on labor pain. Such women have normal sensory and psychometric test results, except for significantly higher cuff pressure pain. We find an excess of heterozygotes carrying the rare allele of SNP rs140124801 in KCNG4. The rare variant K6.4-Met419 has a dominant-negative effect and cannot modulate the voltage dependence of K2.1 inactivation because it fails to traffic to the plasma membrane. In vivo, Kcng4 (K6.4) expression occurs in 40% of retrograde-labeled mouse uterine sensory neurons, all of which express K2.1, and over 90% express the nociceptor genes Trpv1 and Scn10a. In neurons overexpressing K6.4-Met419, the voltage dependence of inactivation for K2.1 is more depolarized compared with neurons overexpressing K6.4. Finally, K6.4-Met419-overexpressing neurons have a higher action potential threshold. We conclude that K6.4 can influence human labor pain by modulating the excitability of uterine nociceptors.