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Papers of the Week

Papers: 18 Jul 2020 - 24 Jul 2020


Human Studies

2020 Jul 17

J Gastroenterol

Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort.


Dunbar E, Greer PJ, Melhem N, Alkaade S, Amann ST, Brand R, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda NM, Larusch J, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Wilcox CM, et al.
J Gastroenterol. 2020 Jul 17.
PMID: 32681239.


Pain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associated genes are associated with a constant-severe pain experience in RAP/CP patients.