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Papers of the Week

Papers: 18 Jul 2020 - 24 Jul 2020

Human Studies, Pharmacology/Drug Development

2020 Jul 17

Adv Ther

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP3652 in First-in-Human and Ascending Multiple Oral Dose Studies in Healthy Subjects.


Takizawa M, Cerneus D, Michon I, Rijnders S, van der Heide D, Meijer J, Stoelzel M, Sato Y
Adv Ther. 2020 Jul 17.
PMID: 32681461.


Inhibitors of fatty acid amide hydrolase (FAAH) increase the levels of endocannabinoids and have shown analgesic and anti-inflammatory activity in animal models. ASP3652 is a peripherally acting FAAH inhibitor in development for the treatment of chronic bladder and pelvic pain disorders. Here we describe the safety, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of ASP3652 administered in healthy non-elderly and elderly male and female volunteers.