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Papers of the Week

2020 Jul 13

Spine J

Small Molecule Antagonist of C-C Chemokine Receptor 1 (CCR1) Reduces Disc Inflammation in the Rabbit Model.


Chou P-H, Chee A, Shi P, Lin C-L, Zhao Y, Zhang L, An HS
Spine J. 2020 Jul 13.
PMID: 32673730.


Targeting chemokines or chemokine receptors is a promising treatment strategy for diseases with chronic inflammation such as rheumatoid arthritis and discogenic pain. Identifying specific molecules and determining their effectiveness in animal models are the first steps in developing these treatments. Macrophage markers have been detected in the intervertebral disc tissues of patients with disc degenerative disease and discogenic pain and in different animal models. Macrophage recruitment into the disc may play a role in initiation of inflammation and if unresolved may lead to chronic inflammation and subsequent back pain.