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Papers: 18 Jul 2020 - 24 Jul 2020
Human Studies, Pharmacology/Drug Development
2020 Jul 01
JAMA Netw Open
3
7
Sickle cell disease (SCD) is characterized by chronic pain and episodic acute pain caused by vasoocclusive crises, often requiring high doses of opioids for prolonged periods. In humanized mouse models of SCD, a synthetic cannabinoid has been found to attenuate both chronic and acute hyperalgesia. The effect of cannabis on chronic pain in adults with SCD is unknown.