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Papers of the Week

Papers: 18 Jul 2020 - 24 Jul 2020

Human Studies, Pharmacology/Drug Development

2020 Jul 01

JAMA Netw Open



Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial.


Abrams DI, Couey P, Dixit N, Sagi V, Hagar W, Vichinsky E, Kelly M E, Connett JE, Gupta K
JAMA Netw Open. 2020 Jul 01; 3(7):e2010874.
PMID: 32678452.


Sickle cell disease (SCD) is characterized by chronic pain and episodic acute pain caused by vasoocclusive crises, often requiring high doses of opioids for prolonged periods. In humanized mouse models of SCD, a synthetic cannabinoid has been found to attenuate both chronic and acute hyperalgesia. The effect of cannabis on chronic pain in adults with SCD is unknown.