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Papers of the Week

Papers: 18 Jul 2020 - 24 Jul 2020

Animal Studies

2020 Jul 14

Physiol Behav

Pain behaviour assessments by gait and weight bearing in surgically induced osteoarthritis and inflammatory arthritis.


Ängeby Möller K, Aulin C, Baharpoor A, Svensson CI
Physiol Behav. 2020 Jul 14:113079.
PMID: 32679132.


Osteoarthritis (OA) is the most common cause of joint pain. Animal models and relevant assays for measurement of pain-related behaviours are important tools for studies of mechanisms inducing and sustaining pain in OA. The aim of this study was to evaluate two different assessments of weight bearing; stationary and during locomotion, and to explore their feasibility to detect analgesic effects in vivo. Two fundamentally different mouse models of joint arthritis were investigated; surgical transection of the anterior cruciate ligament (ACLT) resulting in destabilization of the joint with subsequent structural deterioration resembling OA, and monoarthritis induced by injection of Complete Freund´s Adjuvant (CFA) into the ankle joint capsule.