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Papers of the Week

Papers: 11 Jul 2020 - 17 Jul 2020

Animal Studies, Pharmacology/Drug Development

2020 Jul 10


Mitochondrial bioenergetics, glial reactivity and pain-related behavior can be restored by dichloroacetate treatment in rodent pain models.


Lagos-Rodríguez V, Martínez-Palma L, Marton S, Miquel E, Escobar-Pintos R, Cassina A, Lago N, Cassina P
Pain. 2020 Jul 10.
PMID: 32658145.


Glial reactivity in the dorsal horn of the spinal cord is a hallmark in most chronic pain conditions. Neuroinflammation-associated reactive glia, in particular astrocytes, have been shown to exhibit reduced mitochondrial respiratory function.Here we studied the mitochondrial function at the lumbar spinal cord tissue from Complete Freund's adjuvant (CFA)-induced inflammatory pain rat and chronic constriction injury (CCI) mouse models by high resolution respirometry (HRR). A significant decrease in mitochondrial bioenergetic parameters at the injury-related spinal cord level coincided with highest astrocytosis. Oral administration of dichloroacetate (DCA) significantly increased mitochondrial respiratory function by inhibiting pyruvate dehydrogenase kinase (PDK) and decreased GFAP and Iba-1 immunoreactivity in spinal cord. Importantly, DCA treatment significantly reduced the ipsilateral pain-related behavior without affecting contralateral sensitivity in both pain models. Our results indicate that mitochondrial metabolic modulation with DCA may offer an alternative therapeutic strategy to alleviate chronic and persistent inflammatory pain.